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Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins

United States Patent

November 3, 2009
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.
Schmidt; Jurgen G. (Los Alamos, NM), Boyer; Anne E. (Atlanta, GA), Kalb; Suzanne R. (Atlanta, GA), Moura; Hercules (Tucker, GA), Barr; John R. (Suwannee, GA), Woolfitt; Adrian R. (Atlanta, GA)
Los Alamos National Security, LLC (Los Alamos, NM)
10/ 980,346
November 3, 2004
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.