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Direct imaging of neural currents using ultra-low field magnetic resonance techniques

United States Patent

August 11, 2009
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.
Volegov; Petr L. (Los Alamos, NM), Matlashov; Andrei N. (Los Alamos, NM), Mosher; John C. (Los Alamos, NM), Espy; Michelle A. (Los Alamos, NM), Kraus, Jr.; Robert H. (Los Alamos, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
11/ 678,023
February 22, 2007
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under U.S. Department of Energy Contract No. W-7405-ENG-36. Accordingly, the United States Government has certain rights in the invention.