Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by molecular recognition events in addition to providing signaling the presence and/or identity of a target molecule. Methods, including solid phase synthesis techniques, for making probe molecules that exhibit changes in their optical properties upon target molecule binding are described in the disclosure. Also disclosed herein are novel chromophore moieties, which have tailored fluorescent emission spectra.
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT
This invention was made with government support under contract number GM065306 awarded by the National Institutes of Health, contract number W-7405-ENG-36 awarded by the Department of Energy to the Los Alamos National Laboratories, and by subcontract number 28893001035 awarded by the Los Alamos National Laboratories. The government has certain rights in this invention.