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Visual-servoing optical microscopy

United States Patent

June 9, 2009
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time: quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
Callahan; Daniel E. (Martinez, CA), Parvin; Bahram (Hercules, CA)
The Regents of the University of California (Oakland, CA)
10/ 296,870
June 7, 2001
This invention was made, in part, with Government support by the Department of Energy, Contract No. DE-AC03-76SF00098. The Government has certain rights in the invention.