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Methods and materials for the production of L-lactic acid in yeast

United States Patent

May 19, 2009
View the Complete Patent at the US Patent & Trademark Office
Recombinant yeast are provided having, in one aspect, multiple exogenous LDH genes integrated into the genome, while leaving native PDC genes intact. In a second aspect, recombinant yeast are provided having an exogenous LDH gene integrated into its genome at the locus of a native PDC gene, with deletion of the native PDC gene. The recombinant yeast are useful in fermentation process for producing lactic acid.
Hause; Ben (Jordan, MN), Rajgarhia; Vineet (Minnetonka, MN), Suominen; Pirkko (Maple Grove, MN)
Cargill, Inc. (Wayzata, MN)
10/ 452,038
May 30, 2003
This invention was made with U.S. Government support under Contract No. DE-FC-36-00GO10598, awarded by the Department of Energy. The U.S. government has certain rights in this invention.