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Biosensors based on directed assembly of particles

United States Patent

7,485,419
February 3, 2009
View the Complete Patent at the US Patent & Trademark Office
A sensor system for detecting an effector or cofactor comprises (a) a nucleic acid enzyme; (b) a substrate for the nucleic acid enzyme, comprising a first polynucleotide; (c) a first set of particles comprising a second polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to the particles at its 3' terminus; and (d) a second set of particles comprising a third polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to the particles at its 5' terminus.
Lu; Yi (Champaign, IL), Liu; Juewen (Urbana, IL)
The Board of Trustees of the University of Illinois (Urbana, IL)
10/ 756,825
20090011402
January 13, 2004
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The subject matter of this application may in part have been funded by the Department of Energy (DEFG02-01ER63179) and the National Science Foundation (DMR-0117792). The government may have certain rights in this invention.