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Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications

United States Patent

January 6, 2009
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined array. The hybrid magnetic structure provides means for separation and other biotechnology applications involving holding, manipulation, or separation of magnetizable molecular structures and targets. Also disclosed are hybrid magnetic tweezers able to exert approximately 1 nN of force to 4.5 .mu.m magnetic bead. The maximum force was experimentally measured to be .about.900 pN which is in good agreement with theoretical estimations and other measurements. In addition, a new analysis scheme that permits fast real-time position measurement in typical geometry of magnetic tweezers has been developed and described in detail.
Humphries; David E. (El Cerrito, CA), Hong; Seok-Cheol (Seoul, KR), Cozzarelli, legal representative; Linda A. (Berkeley, CA), Pollard; Martin J. (El Cerrito, CA), Cozzarelli; Nicholas R. (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
11/ 355,462
February 15, 2006
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made during work supported by U.S. Department of Energy under Contract No. DE-AC03-76SF00098, now DE-AC02-05CH11231. The government has certain rights in this invention.