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Superactive cellulase formulation using cellobiohydrolase-1 from Penicillium funiculosum

United States Patent

November 11, 2008
View the Complete Patent at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
Cellulase Enzymes for the Conversion of Biomass to Biofuels and Chemicals
Cellulase Enzymes for the Conversion of Biomass to Biofuels and Chemicals
Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native enzyme, as well as recombinantly expressed enzyme, for example, that enzyme expressed in a non-native Aspergillus host. In a specific example, the specific performance of the formulation using purified recombinant Cel7A from Penicillium funiculosum expressed in A. awamori is increased by more than 200% when compared to a formulation using purified Cel7A from Trichoderma reesei.
Adney; William S. (Golden, CO), Baker; John O. (Golden, CO), Decker; Stephen R. (Berthoud, CO), Chou; Yat-Chen (Golden, CO), Himmel; Michael E. (Littleton, CO), Ding; Shi-You (Golden, CO)
Alliance For Sustainable Energy, LLC (Golden, CO)
10/ 557,589
February 27, 2003
CONTRACTUAL ORIGIN OF THE INVENTION The United States Government has rights in this invention under Contract No. DE-AC36-99GO-10337 between the United States Department of Energy and the National Renewable Energy Laboratory, a division of Midwest Research Institute.