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Membrane architectures for ion-channel switch-based electrochemical biosensors

United States Patent

October 28, 2008
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The present invention is directed to a process of forming a bilayer lipid membrane structure by depositing an organic layer having a defined surface area onto an electrically conductive substrate, removing portions of said organic layer upon said electrically conductive substrate whereby selected portions of said organic layer are removed to form defined voids within said defined surface area of said organic layer and defined islands of organic layer upon said electrically conductive substrate, and, depositing a bilayer lipid membrane over the defined voids and defined islands of organic layer upon said substrate whereby aqueous reservoirs are formed between said electrically conductive substrate and said bilayer lipid membrane, said bilayer lipid membrane characterized as spanning across the defined voids between said defined islands. A lipid membrane structure is also described together with an array of such lipid membrane structure.
Sansinena; Jose-Maria (Los Alamos, NM), Redondo; Antonio (Los Alamos, NM), Swanson; Basil I. (Los Alamos, NM), Yee; Chanel Kitmon (Davis, CA), Sapuri/Butti; Annapoorna R. (Davis, CA), Parikh; Atul N. (Woodland, CA), Yang; Calvin (Davis, CA)
Los Alamos National Security, LLC (Los Alamos, NM)
11/ 072,720
March 4, 2005
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.