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Site specific incorporation of keto amino acids into proteins

United States Patent

October 7, 2008
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
Schultz; Peter G. (La Jolla, CA), Wang; Lei (San Diego, CA)
The Scripps Research Institute (La Jolla, CA)
10/ 530,421
October 15, 2003
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT The invention was made with United States Government support for a portion of the work described herein under Grant No. GM62159 from the National Institutes of Health, and support under grant DE-FG03-00ER45812 and grant DE-AC03-76SF00098 from the Department of Energy, and support under grant number N0001498D0402 from the Office of Naval Research. The United States Government has certain rights in the invention.