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Cellobiohydrolase I gene and improved variants

United States Patent

May 20, 2008
View the Complete Patent at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
Cellulase Enzymes for the Conversion of Biomass to Biofuels and Chemicals
The disclosure provides a method for preparing an active exoglucanase in a heterologous host of eukaryotic origin. The method includes mutagenesis to reduce glycosylation of the exoglucanase when expressed in a heterologous host. It is further disclosed a method to produce variant cellobiohydrolase that is stable at high temperature through mutagenesis.
Adney; William S. (Golden, CO), Decker; Stephen R. (Berthoud, CO), Mc Carter; Suzanne (San Carlos, CA), Baker; John O. (Golden, CO), Nieves; Raphael (Lakewood, CO), Himmel; Michael E. (Littleton, CO), Vinzant; Todd B. (Golden, CO)
MidWest Research Institute (Kansas City, MO)
10/ 031,496
January 14, 2002
The United States Government has rights in this invention under contract number DE-AC36-99G0-10337 between the United States Department of Energy and the National Renewable Energy Laboratory, a division of the Midwest Research Institute.