This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.
STATEMENT OF GOVERNMENT INTERESTS
This invention was made with government support under grant numbers DE-FG02-87ER-60565 from the Department of Energy and NIH U01HL066678 from the National Institutes of Health. The Government has certain rights in the invention.