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Detection and recognition of analytes based on their crystallization patterns

United States Patent

May 6, 2008
View the Complete Patent at the US Patent & Trademark Office
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization pattern") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. It has been shown that changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. It was also found that both the character of changer in the crystallization patter and the fact of such changes can be used as recognition elements in analysis of protein molecules.
Morozov; Victor (Manassas, VA), Bailey; Charles L. (Cross Junction, VA), Vsevolodov; Nikolai N. (Kensington, MD), Elliott; Adam (Manassas, VA)
George Mason Intellectual Properties, Inc. (Fairfax, VA)
11/ 397,908
April 5, 2006
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of DOE Grant No. DE-F C52-04NA25455 awarded by the U.S. Department of Energy.