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Permeabilizing biofilms

United States Patent

February 19, 2008
View the Complete Patent at the US Patent & Trademark Office
Methods for permeabilizing biofilms using stress waves are described. The methods involve applying one or more stress waves to a biofilm, e.g., on a surface of a device or food item, or on a tissue surface in a patient, and then inducing stress waves to create transient increases in the permeability of the biofilm. The increased permeability facilitates delivery of compounds, such as antimicrobial or therapeutic agents into and through the biofilm.
Soukos; Nikolaos S. (Revere, MA), Lee; Shun (Arlington, VA), Doukas; Apostolos G. (Belmont, MA)
The General Hospital Corporation (Boston, MA)
10/ 019,837
May 12, 2000
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The U.S. Government may have certain rights in this invention pursuant to Grant No. DE-FG02-91ER61228 awarded by the U.S. Department of Energy.