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Automated macromolecular crystal detection system and method

United States Patent

7,227,983
June 5, 2007
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
An automated macromolecular method and system for detecting crystals in two-dimensional images, such as light microscopy images obtained from an array of crystallization screens. Edges are detected from the images by identifying local maxima of a phase congruency-based function associated with each image. The detected edges are segmented into discrete line segments, which are subsequently geometrically evaluated with respect to each other to identify any crystal-like qualities such as, for example, parallel lines, facing each other, similarity in length, and relative proximity. And from the evaluation a determination is made as to whether crystals are present in each image.
Christian; Allen T. (Tracy, CA), Segelke; Brent (San Ramon, CA), Rupp; Bernard (Livermore, CA), Toppani; Dominique (Fontainebleau, FR)
The Regents of the University of California (Oakland, CA)
10/ 452,668
20070122025
May 30, 2003
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.