Skip to Content
Find More Like This
Return to Search

Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same

United States Patent

May 29, 2007
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Functional Apolipoprotein A-I mutant proteins, having one or more cysteine substitutions and polynucleotides encoding same, can be used to modulate paraoxonase's arylesterase activity. These ApoA-I mutant proteins can be used as therapeutic agents to combat cardiovascular disease, atherosclerosis, acute phase response and other inflammatory related diseases. The invention also includes modifications and optimizations of the ApoA-I nucleotide sequence for purposes of increasing protein expression and optimization.
Oda; Michael N. (Benicia, CA), Forte; Trudy M. (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
10/ 342,965
January 14, 2003
STATEMENT OF GOVERNMENT SUPPORT This invention was made during work partially supported through the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. The government has certain rights in this invention.