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pH-sensitive methacrylic copolymer gels and the production thereof

United States Patent

May 15, 2007
View the Complete Patent at the US Patent & Trademark Office
Ames Laboratory - Visit the Iowa State University Research Foundation - Office of Intellectual Property & Technology Transfer Website
The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.
Mallapragada; Surya K. (Ames, IA), Anderson; Brian C. (Lake Bluff, IA)
Iowa State University Research Foundation (Ames, IA)
10/ 366,864
February 14, 2003
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The present invention was developed using financial support provided by the U.S. Department of Energy under contract number W-7405-ENG-82. The United States Government has certain rights in the present invention.