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Anatomic and functional imaging of tagged molecules in animals

United States Patent

April 24, 2007
View the Complete Patent at the US Patent & Trademark Office
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Anatomic and Functional Imaging of Tagged Molecules in Animals
A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.
Weisenberger; Andrew G. (Yorktown, VA), Majewski; Stanislaw (Grafton, VA), Paulus; Michael J. (Knoxville, TN), Gleason; Shaun S. (Knoxville, VA)
Jefferson Solence Ass. LLC (Newport News, VA)
10/ 341,715
January 14, 2003
The United States of America may have certain rights to this invention under Management and Operating Contract No. DE-AC05-84ER40150 from the Department of Energy.