Skip to Content
Find More Like This
Return to Search

Anatomic and functional imaging of tagged molecules in animals

United States Patent

7,209,579
April 24, 2007
View the Complete Patent at the US Patent & Trademark Office
Thomas Jefferson National Accelerator Facility - Visit the Technology Review Committee Website
Anatomic and Functional Imaging of Tagged Molecules in Animals
A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.
Weisenberger; Andrew G. (Yorktown, VA), Majewski; Stanislaw (Grafton, VA), Paulus; Michael J. (Knoxville, TN), Gleason; Shaun S. (Knoxville, VA)
Jefferson Solence Ass. LLC (Newport News, VA)
10/ 341,715
January 14, 2003
The United States of America may have certain rights to this invention under Management and Operating Contract No. DE-AC05-84ER40150 from the Department of Energy.