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Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria

United States Patent

April 3, 2007
View the Complete Patent at the US Patent & Trademark Office
A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.
DiSpirito; Alan A. (Ames, IA), Zahn; James A. (Harbor Beach, MI), Graham; David W. (Lawrence, KS), Kim; Hyung J. (St. Paul, MN), Alterman; Michail (Lawrence, KS), Larive; Cynthia (Lawrence, KS)
The University of Kansas (Lawrence, KS), Iowa State University Research Foundation, Inc. (Ames, IA)
10/ 741,831
December 19, 2003
GRANT REFERENCE CLAUSE This invention was funded in part by Department of Energy Grant No. 02-96ER20237. The government may have certain rights in this invention.