The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.
This invention was made, in part, with funding from the National Science Foundation under Grant No. CHE-9610254 and from the Department of Energy under Grant No. FG02-98ER 24873. Therefore, the United States of America may have certain rights in the invention.