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Synthetic heparin-binding growth factor analogs

United States Patent

January 23, 2007
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.
Pena; Louis A. (Poquott, NY), Zamora; Paul (Gaithersburg, MD), Lin; Xinhua (Plainview, NY), Glass; John D. (Shoreham, NY)
BioSurface Engineering Technologies, Inc. (Rockville, MD), Brookhaven National Laboratory (Upton, NY)
10/ 224,268
August 20, 2002
This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.