The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
This invention was made with government support under the National Institutes of Health (Grant GM36397) and the Department of Energy (Grant DE-FG07-96ER20257). The U.S. Government may have certain rights in this invention.