Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
The U.S. Government has certain rights in this invention pursuant to Grant Nos. DAAK-60-97-K-9503 administered by the Defense Advanced Research Projects Agency, DAAG55-97-1-0187 and DAAG55-98-1-0266, both administered by the United States Army, DE-FG03-98NV13367 administered by the Department of Energy, and NAS-1407 administered by the National Aeronautics and Space Administration.