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Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs

United States Patent

August 1, 2006
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Schultz; Peter (La Jolla, CA), Wang; Lei (San Diego, CA), Anderson; John Christopher (San Diego, CA), Chin; Jason (San Diego, CA), Liu; David R. (Lexington, MA), Magliery; Thomas J. (North Haven, CT), Meggers; Eric L. (La Jolla, CA), Mehl; Ryan Aaron (San Diego, CA), Pastrnak; Miro (San Diego, CA), Santoro; Stephen William (San Diego, CA), Zhang; Zhiwen (San Diego, CA)
The Scripps Research Institute (La Jolla, CA), The Regents of the University of California (Oakland, CA)
10/ 126,931
April 19, 2002
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT The invention was made with United States Government support under Contract No. ONR-6502573 from the Office of Naval Research, Contract No. NIH GM62159 from the National Institutes of Health, and Contract Nos. DE-FG03-00ER45812, DE-AC03-76SF00098 from the Department of Energy. The United States Government has certain rights in the invention.