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Production of a highly active, soluble form of the cytochrome P450 reductase (CPR A) from Candida tropicalis

United States Patent

August 1, 2006
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal region. Also provided are host cells comprising the subject soluble CPR proteins. In addition, the present invention provides nucleotide and corresponding amino acid sequences for soluble CPR proteins and vectors comprising the nucleotide sequences. Methods for producing a soluble CPR, for increasing production of a dicarboxylic acid, and for detecting a cytochrome P450 are also provided.
Donnelly; Mark (Warrenville, IL)
Cognis Corporation (Ambler, PA)
10/ 272,017
October 15, 2002
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under WFO Agreement No. 85J04, Prime Contract No. W-31-109-ENG-38 awarded by the Department of Energy. The United States Government has certain rights in the invention.