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Multiple stimulus reversible hydrogels

United States Patent

April 25, 2006
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.
Gutowska; Anna (Richland, WA), Krzyminski; Karol J. (Poland, PL)
Battelle Memorial Institute (Richland, WA)
10/ 701,053
November 3, 2003
This invention was made with Government support under Contract No. DE-AC06-76RL01830 awarded by the U.S. Department of Energy. The U.S. Government has certain rights in the invention.