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Method of treating tumors

United States Patent

April 18, 2006
View the Complete Patent at the US Patent & Trademark Office
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
DeNardo; Sally J. (El Macerco, CA), Burke; Patricia A. (Sacramento, CA), DeNardo; Gerald L. (El Macerco, CA), Goodman; Simon (Darmstadt, DE), Matzku, legal representative; Kerstin (Zwingenberg, DE), Matzku, deceased; Siegfried (Zwingenberg, DE)
The Regents of the University of California (Oakland, CA), Merck Patent GmbH (Darmstadt, DE)
10/ 208,931
July 31, 2002
STATEMENT OF GOVERNMENT INTEREST A portion of the work described herein was supported by grant number PO1 CA-47829 from the National Cancer Institute, and by grants number DEFG01-00NE22944 and DEFG03-84ER60233 from the United States Department of Energy. The United States Government may retain certain rights in this invention.