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Carboranylporphyrins and uses thereof

United States Patent

February 7, 2006
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.
Wu; Haitao (Wading River, NY), Miura; Michiko (Hampton Bay, NY)
Brookhaven Science Associates, LLC (Upton, NY)
10/ 848,741
May 20, 2004
This invention was made with Government support under contract number DE-AC02-098CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.