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Methods for identifying an essential gene in a prokaryotic microorganism

United States Patent

January 31, 2006
View the Complete Patent at the US Patent & Trademark Office
Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombination. This system offers an enhanced means of identifying essential function genes in diploid pathogens, such as gram-negative and gram-positive bacteria.
Shizuya; Hiroaki (South Pasadena, CA)
California Institute of Technology (Pasadena, CA)
09/ 896,509
June 28, 2001
This invention was made in part with government support under Department of Energy Grant No. DE-FG03-99ER62855/S-95,206. The government has certain rights in this invention.