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Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

United States Patent

October 11, 2005
View the Complete Patent at the US Patent & Trademark Office
This invention provides methods of detecting molecules at an interface, which comprise labeling the molecules with a second harmonic-active moiety and detecting the labeled molecules at the interface using a surface selective technique. The invention also provides methods for detecting a molecule in a medium and for determining the orientation of a molecular species within a planar surface using a second harmonic-active moiety and a surface selective technique.
Salafsky; Joshua S. (New York, NY), Eisenthal; Kenneth B. (Ridgewood, NJ)
The Trustees of Columbia University in the City of New York (New York, NY)
09/ 731,366
December 6, 2000
Government support under grant number CHE-96-12685 from the National Science Foundation and grant numbers DE-FG02-91ER and DE-FG02-14226 from the Department of Energy. Accordingly, the U.S. Government has certain rights in this invention.