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Methods for detection of ataxia telangiectasia mutations

United States Patent

October 4, 2005
View the Complete Patent at the US Patent & Trademark Office
The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.
Gatti; Richard A. (Sherman Oaks, CA)
The Regents of the University of California (Oakland, CA)
10/ 175,225
June 17, 2002
GOVERNMENT RIGHTS This invention was made with Government support under Grant No. DEFG0387ER60548, awarded by the Department of Energy, and Grant No. NS35311, awarded by the National Institutes of Health. The Government has certain rights in this invention.