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Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

United States Patent

October 4, 2005
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.
Miura; Michiko (Hampton Bays, NY), Slatkin; Daniel N. (Southold, NY)
Brookhaven Science Associates, LLC (Upton, NY)
10/ 375,454
February 27, 2003
This invention was made with Government support under contract number DE-AC 02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.