The present invention provides CNS sequences that regulate the cytokine gene expression, expression cassettes and vectors comprising or lacking the CNS sequences, host cells and non-human transgenic animals comprising the CNS sequences or lacking the CNS sequences. The present invention also provides methods for identifying compounds that modulate the functions of CNS sequences as well as methods for diagnosing defects in the CNS sequences of patients.
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
The present invention was made under funding from the United States Department of Energy under Contract DE-AC03-76SF0098 for the management and operation of the Lawrence Berkeley National Laboratory. The present invention was also made under funding from NIH GM-5748202 (K.A.F.), HHMI AI30663 and NIH HL56385 (R.M.L.). The United States Government has certain rights to this invention.