The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of preparing the compounds of the invention, as well as methods of using the compounds in magnetic resonance imaging applications.
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
This invention was made with support awarded by the Department of Energy, Contract No. DE-ACO3-76SF00098, and The Government of the United States of America, NIH Grant No. DK57814 and NIH Grant No. HL69832. The United States Government may have certain rights in this invention.