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Piperazine-based nucleic acid analogs

United States Patent

January 11, 2005
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.
Schmidt; Jurgen (Los Alamos, NM), Silks; Louis A. (White Rock, NM), Michalczyk; Ryszard (Santa Fe, NM)
The Regents of the University of California (Oakland, CA)
10/ 171,073
June 13, 2002
GOVERNMENT RIGHTS This invention was made with Government support under. Contract. Number W-7405-ENG-36 awarded by the United States Department of Energy to The Regents of the University of California. The Government has certain rights in the invention.