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Passive injection control for microfluidic systems

United States Patent

December 21, 2004
View the Complete Patent at the US Patent & Trademark Office
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Apparatus for eliminating siphoning, "dead" regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive injection control for both electric field-driven and pressure-driven systems by providing additional fluid flow channels or auxiliary channels disposed on either side of a sample separation column. The auxiliary channels are sized such that volumetric fluid flow rate through these channels, while sufficient to move the sample away from the sample injection region in a timely fashion, is less than that through the sample separation channel or chromatograph.
Paul; Phillip H. (Livermore, CA), Arnold; Don W. (Livermore, CA), Neyer; David W. (Castro Valley, CA)
Sandia National Laboratories (Livermore, CA)
10/ 341,870
January 13, 2003
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.