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Metalloporphyrins and their uses as radiosensitizers for radiation therapy

United States Patent

July 6, 2004
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.
Miura; Michiko (Hampton Bays, NY), Slatkin; Daniel N. (Southold, NY)
Brookhaven Science Associates, LLC (Upton, NY)
10/ 117,010
April 5, 2002
This invention was made with U.S. government support under U.S. Department of Energy Contract No. DE-AC02-98CH10886 with Brookhaven National Laboratory. The U.S. Government has certain rights in the invention.