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Self assembling proteins

United States Patent

June 29, 2004
View the Complete Patent at the US Patent & Trademark Office
Novel fusion proteins capable of self-assembling into regular structures, as well as nucleic acids encoding the same, are provided. The subject fusion proteins comprise at least two oligomerization domains rigidly linked together, e.g. through an alpha helical linking group. Also provided are regular structures comprising a plurality of self-assembled fusion proteins of the subject invention, and methods for producing the same. The subject fusion proteins find use in the preparation of a variety of nanostructures, where such structures include: cages, shells, double-layer rings, two-dimensional layers, three-dimensional crystals, filaments, and tubes.
Yeates; Todd O. (Agoura Hills, CA), Padilla; Jennifer (Los Angeles, CA), Colovos; Chris (Thousand Oaks, CA)
The Regents of the University of California (Oakland, CA)
09/ 564,710
May 3, 2000
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with Government support under Grant No. DE-FGO3-87ER60615 awarded by the Department of Energy and Grant No. GM31299 awarded by the National Institute of Health. The Government has certain rights in this invention.