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Human AZU-1 gene, variants thereof and expressed gene products

United States Patent

June 22, 2004
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, isolation and characterization of AZU-1 and AZU-2 genes localized to a tumor suppressive locus at chromosome 10q26, highly expressed in nonmalignant and premalignant cells derived from a human breast tumor progression model. A recombinant full length protein sequences encoded by the AZU-1 gene and nucleotide sequences of AZU-1 and AZU-2 genes and variant and fragments thereof. Monoclonal or polyclonal antibodies specific to AZU-1, AZU-2 encoded protein and to AZU-1, or AZU-2 encoded protein homologs.
Chen; Huei-Mei (Richmond, CA), Bissell; Mina (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
09/ 344,624
June 25, 1999
The United States Government has certain rights in this invention pursuant to Contract DE-AC03-76SF00098 between the United States Department of Energy and the University of California.