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Methods for production of proteins in host cells

United States Patent

January 13, 2004
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
The present invention provides methods for the production of proteins, particularly toxic proteins, in host cells. The invention provides methods which use a fusion protein comprising a chaperonin binding domain in host cells induced or regulated to have increased levels of chaperonin which binds the chaperonin binding domain.
Donnelly; Mark (Warrensville, IL), Joachimiak; Andrzej (Bolingbrook, IL)
Genecor International, Inc. (Rochester, NY)
09/ 470,830
December 23, 1999
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under Grant No. 70NANB5H1138 awarded by Advanced Technology Program/National Institute of Standards and Technology. The Government has certain rights in this invention. This Invention was made with Government support under ANL Work-for-Others Proposal No. P-95090; Prime Contract W-31-198-ENG-38 awarded by the Department of Energy. The Government has certain rights In this Invention.