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Method and apparatus for high resolution ex-situ NMR spectroscopy

United States Patent

January 6, 2004
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.
Pines; Alexander (Berkeley, CA), Meriles; Carlos A. (El Cerrito, CA), Heise; Henrike (Goettingen, DE), Sakellariou; Dimitrios (Oakland, CA), Moule; Adam (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
10/ 218,974
August 13, 2002
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under Contract No. DE-AC03-76SF00098, awarded by the Department of Energy. The Government has certain rights in this invention.