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Inhibition of molecular and biological processes using modified oligonucleotides

United States Patent

April 15, 2003
View the Complete Patent at the US Patent & Trademark Office
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
Kozyavkin; Sergei A. (Germantown, MD), Malykh; Andrei G. (Germantown, MD), Polouchine; Nikolai N. (Montgomery Village, MD), Slesarev; Alexei I. (Germantown, MD)
Fidelity Systems, Inc. (Gaithersburg, MD)
09/ 655,804
September 5, 2000
This invention was made with government support, including a grant, Grant No. DE-FG02-98ER82557, from the U.S. Department of Energy, and a grant, Grant No. R44-GM55485, from the U.S. National Institutes of Health. The U.S. government may have certain rights in the invention.