A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
This invention was made with government support, including a grant, Grant No. DE-FG02-98ER82557, from the U.S. Department of Energy, and a grant, Grant No. R44-GM55485, from the U.S. National Institutes of Health. The U.S. government may have certain rights in the invention.