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Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids

United States Patent

April 1, 2003
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.
Srivastava; Suresh C. (Setauket, NY), Li; Zizhong (Upton, NY), Meinken; George (Middle Island, NY)
Brookhaven Science Associates, LLC (Upton, NY)
09/ 847,617
May 2, 2001
This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.