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Method for calibrating mass spectrometers

United States Patent

December 24, 2002
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A method whereby a mass spectra generated by a mass spectrometer is calibrated by shifting the parameters used by the spectrometer to assign masses to the spectra in a manner which reconciles the signal of ions within the spectra having equal mass but differing charge states, or by reconciling ions having known differences in mass to relative values consistent with those known differences. In this manner, the mass spectrometer is calibrated without the need for standards while allowing the generation of a highly accurate mass spectra by the instrument.
Anderson; Gordon A. (Benton City, WA), Brands; Michael D. (Richland, WA), Bruce; James E. (Schwenksville, PA), Pasa-Tolic; Ljiljana (Richland, WA), Smith; Richard D. (Richland, WA)
Battelle Memorial Institute (Richland, WA)
09/ 760,248
January 12, 2001
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Government support under Contract DE-AC06-76RLO 1830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.