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Flowmeter for pressure-driven chromatography systems

United States Patent

October 8, 2002
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
A flowmeter for accurately measuring the flowrate of fluids in high pressure chromatography systems. The flowmeter is a porous bed of a material, the porous bed having a porosity in the range of about 0.1 to 0.6 and a pore size in the range of about 50 nm to 1 .mu.m, disposed between a high pressure pumping means and a chromatography column. The flowmeter is provided with pressure measuring means at both the inlet and outlet of the porous bed for measuring the pressure drop through the porous bed. This flowmeter system provides not only the ability to measure accurately flowrates in the range of .mu.L/min to nL/min but also to provide a signal that can be used for a servo loop or feedback control system for high pressure pumping systems.
Paul; Phillip H. (Livermore, CA), Arnold; Don W. (Livermore, CA)
Sandia National Laboratories (Livermore, CA)
09/ 548,474
April 13, 2000
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.