The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.
STATEMENT OF GOVERNMENT SUPPORT
This application was made with United States Government support under Award Number R29-GM55382 from the National Institutes of Health and Award Number DE-FG02-96ER14678 from the Department of Energy. The U.S. Government has certain rights in this invention.