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Spectroscopic diagnostics for bacteria in biologic sample

United States Patent

April 30, 2002
View the Complete Patent at the US Patent & Trademark Office
A method to analyze and diagnose specific bacteria in a biologic sample using spectroscopy is disclosed. The method includes obtaining the spectra of a biologic sample of a non-infected patient for use as a reference, subtracting the reference from the spectra of an infected sample, and comparing the fingerprint regions of the resulting differential spectrum with reference spectra of bacteria in saline. Using this diagnostic technique, specific bacteria can be identified sooner and without culturing, bacteria-specific antibiotics can be prescribed sooner, resulting in decreased likelihood of antibiotic resistance and an overall reduction of medical costs.
El-Sayed; Mostafa A. (Atlanta, GA), El-Sayed; Ivan H. (Somerville, MA)
Georgia Tech Research Corp. (Atlanta, GA), Boston Medical Center Corp. (Boston, MA)
09/ 624,059
July 24, 2000
This invention is the subject of a grant from the United States Department of Energy, Grant No. #DEFG0297ER14799. The U.S. government may have certain rights in this invention.