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Fluoralkenyl nortropanes

United States Patent

February 5, 2002
View the Complete Patent at the US Patent & Trademark Office
Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.
Goodman; Mark M. (Atlanta, GA), Chen; Ping (Indianapolis, IN)
Emory University (Atlanta, GA)
09/ 553,795
April 21, 2000
ACKNOWLEDGMENT OF FEDERAL RESEARCH SUPPORT This invention was made, at least in part, with funding from the United States Department of Energy under contract #DE-FG02-97ER-62367. Accordingly, the U.S. government may have certain rights in this invention.