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Gastrin receptor-avid peptide conjugates

United States Patent

March 13, 2001
View the Complete Patent at the US Patent & Trademark Office
A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
Hoffman; Timothy J. (Columbia, MO), Volkert; Wynn A. (Columbia, MO), Li; Ning (Baltimore, MD), Sieckman; Gary (Ashland, MO), Higginbotham; C. A. (Columbia, MO)
The Curators of the University of Missouri (Columbia, MO)
09/ 064,499
April 22, 1998
GRANT REFERENCE The research carried out in connection with this invention was supported in part by a grant from the Department of Energy (DOE), grant number DE-FG02-89ER60875, a grant from the U.S. Departnent of Veterans Affairs Medical Research Division and the Department of Radiology MU-C2-02691. The Government has certain rights in the invention.