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Inhibitors of glycogen synthase 3 kinase

United States Patent

November 28, 2000
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.
Schultz; Peter (Oakland, CA), Ring; David B. (Palo Alto, CA), Harrison; Stephen D. (Berkeley, CA), Bray; Andrew M. (Victoria, AU)
Chiron Corporation (Emeryville, CA)
08/ 948,887
October 10, 1997
GOVERNMENT LICENSE RIGHTS The U.S. Government has rights in this invention as provided for by the terms of contract No. DE-AC03-76SF00098 awarded by the Department of Energy (DOE) and by the terms of Postdoctoral Fellowships awarded by the National Science Foundation and the American Cancer Society.